Lexapro (generic name: escitalopram) is a widely prescribed antidepressant belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class. It is commonly used to treat depression and generalized anxiety disorder (GAD). While it is effective for mood improvement and anxiety reduction, some people report weight gain after starting Lexapro.
If you’ve been wondering, “Does Lexapro cause weight gain?” or “How can I prevent weight gain while taking Lexapro?”—this guide will help you understand the connection and provide practical strategies.
What is Lexapro?
Lexapro works by increasing serotonin levels in the brain, improving mood and emotional balance. Doctors often prescribe it because it’s considered one of the better-tolerated SSRIs with fewer side effects compared to older antidepressants.
Common uses include:
- Major Depressive Disorder (MDD)
- Generalized Anxiety Disorder (GAD)
- Panic Disorders (off-label)
- Obsessive-Compulsive Disorder (OCD) (off-label)
Lexapro and Weight Gain: What the Research Says
One of the most discussed side effects of SSRIs, including Lexapro, is weight changes—both weight gain and, in some cases, weight loss.
Does Lexapro Really Cause Weight Gain?
- Short-term use: Many studies show that Lexapro has minimal impact on weight in the first few weeks of treatment.
- Long-term use: After 6 months or more, some patients experience gradual weight gain—often between 2 to 10 pounds.
- Individual differences: Not everyone will gain weight. Genetics, lifestyle, diet, and dosage all influence this side effect.
A 2014 study in the Journal of Clinical Psychiatry found that patients on Lexapro gained an average of 1.4 kg (3 pounds) over 9 months, which is considered moderate compared to other SSRIs.
Why Does Lexapro Cause Weight Gain?
The exact reason is not fully understood, but researchers believe it involves several factors:
1. Metabolism Changes
SSRIs may slightly slow metabolism, making it easier to store calories as fat.
2. Increased Appetite
Lexapro can increase serotonin levels, which affect appetite regulation—leading to cravings, especially for carbohydrates and sweets.
3. Improved Mood
When depression lifts, people may regain their appetite, eat more, and enjoy food again—leading to weight gain.
4. Water Retention
Some individuals experience mild fluid retention, which can cause temporary weight increases.
5. Hormonal Effects
Serotonin interacts with hormones like leptin and insulin, which may alter fat storage and hunger signals.
Factors That Influence Weight Gain on Lexapro
Not everyone will experience the same level of weight change. Factors include:
- Dosage: Higher doses may have a stronger impact on appetite and metabolism.
- Duration: The longer you take Lexapro, the higher the likelihood of weight gain.
- Lifestyle: Diet, exercise, and daily activity level play a major role.
- Genetics: Some people are genetically predisposed to gain weight on antidepressants.
- Other Medications: Combining Lexapro with certain drugs (like mood stabilizers or antipsychotics) can amplify weight gain.
Signs You’re Gaining Weight from Lexapro
You may suspect Lexapro weight gain if you notice:
- Steady weight increase over weeks or months without major diet changes
- Increased hunger or snacking, especially for sweets
- Feeling bloated or retaining water
- Clothes fitting tighter despite normal eating habits
How to Prevent or Manage Lexapro Weight Gain
If you’re benefiting from Lexapro but worried about weight gain, these strategies can help:
1. Monitor Your Weight Early
Weigh yourself weekly to detect changes early and take action.
2. Adjust Your Diet
- Focus on lean proteins, vegetables, fruits, and whole grains
- Limit processed foods and sugary snacks
- Watch portion sizes
3. Stay Active
- Aim for 150 minutes of moderate exercise per week
- Include strength training to maintain muscle mass and metabolism
4. Stay Hydrated
Sometimes thirst is mistaken for hunger. Drink plenty of water.
5. Get Enough Sleep
Poor sleep can increase cravings and slow metabolism.
6. Discuss with Your Doctor
If weight gain becomes significant, your doctor may:
- Lower your Lexapro dose
- Switch you to a weight-neutral antidepressant (like bupropion)
- Recommend a nutrition or exercise plan
Alternatives to Lexapro with Lower Weight Gain Risk
If weight gain is a concern, your doctor might consider:
- Bupropion (Wellbutrin) – Often linked to weight loss
- Sertraline (Zoloft) – Lower risk in some patients
- Fluoxetine (Prozac) – Can be weight-neutral in short-term use
⚠ Important: Never stop or change your medication without medical guidance.
Frequently Asked Questions (FAQs) about Lexapro and Weight Gain
1. How much weight can you gain on Lexapro?
Most people experience mild weight gain—about 2 to 10 pounds over several months.
2. Does Lexapro cause belly fat?
Some people notice fat accumulation around the abdomen due to changes in metabolism and appetite, but this varies.
3. Can you lose weight while taking Lexapro?
Yes. With a healthy diet and regular exercise, weight loss is possible even while on Lexapro.
4. How long after starting Lexapro will I gain weight?
Weight gain may begin after 2–6 months of continuous use, but timing varies.
5. Will stopping Lexapro make me lose weight?
Some people lose weight after stopping, but others may not if lifestyle factors remain unchanged.
Tips for Talking to Your Doctor
If Lexapro is improving your mood but causing weight gain, prepare to discuss:
- Your weight history before and after starting Lexapro
- Any new eating habits or cravings
- Exercise routines and lifestyle changes
- Family history of weight gain on antidepressants
A collaborative approach helps balance mental health benefits with physical health concerns.
Balancing Mental Health and Weight
When considering Lexapro weight gain, it’s important to remember:
- Treating depression and anxiety should be the first priority
- Weight gain can be managed with the right strategies
- Mental wellness can make it easier to commit to a healthy lifestyle
Key Takeaways
- Lexapro may cause mild to moderate weight gain in some people, especially with long-term use.
- Causes include metabolism changes, appetite increase, and improved mood.
- Healthy eating, exercise, and regular monitoring can help manage weight.
- Always consult your doctor before making medication changes.
Conclusion
Lexapro weight gain is a real but manageable side effect for many people. While it’s natural to be concerned about changes in your body, your mental health improvement should remain a priority. With the right combination of diet, exercise, and medical support, you can maintain a healthy weight while benefiting from Lexapro’s mood-enhancing effects.
If you’re struggling, talk openly with your healthcare provider—they can help you find a solution that supports both your emotional and physical well-being.